Microcrystalline cellulose as a tablet excipient
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Microcrystalline cellulose as a tablet excipient a study of the relationship between the physical propertiesof microcrystalline cellulose powder, its consolidation behaviour and the characteristics of tablets containing it. by David George Sixsmith

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Published by The author in Bradford .
Written in English


Book details:

Edition Notes

Ph.D. thesis. Typescript.

SeriesTheses
The Physical Object
Pagination272p.
Number of Pages272
ID Numbers
Open LibraryOL21504706M

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microcrystalline cellulose (MCC) is an excipient that can play the roles of almost every category listed above for tablet research. Because of this, MCC is the most versatile and user friendly excipient among numerous available. The development of MCC has made an extremely valuable tabletting agent available to the pharmaceutical industry. Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam Laila H. Emara a*, Ahmed A. El-Ashmawy a, Nesrin F. Taha, Khaled A. El-Shaffei b, El-Sayed M. Mahdey b, Heba K. El-. Excipient – Microcrystalline Cellulose. Microcrystalline cellulose (MCC) is a free-flowing crystalline powder (a non-fibrous microparticle). It is insoluble in water, dilute acids and most organic solvents, but slightly soluble in the alkali solution of 20%. It has a wide range of uses in the pharmaceutical excipients and can be directly. Introduction into Microcrystalline Cellulose. News on Microcrystalline Cellulose. Particle size distribution (PSD) variability in excipients affects mixing. In response, manufacturers rely on raw material control and rigidly defined process parameters to achieve quality. Anti-obesity effect with reduced adverse effect of the co.

A catalogue record for this book is available from the British Library. FDA Inactive Ingredients Database (oral capsules, tablets, and sublingual tablets). Included in nonparenteral medicines licensed in the UK. Included Excipient: microcrystalline cellulose (Avicel PH-I 02); manufacturer: FMC Biopolymer. magnification: x ; voltage.   In this method, amorphous silicon dioxide (SiO2) is used as companion excipient for co-processing with low compressible MCC grades. Cellulose/SiO2 ratio is and resulted product is called lubricated or silisified microcrystalline cellulose (SMCC). This causes the tablet structure to rupture and disintegrate, making increased surfaces for improved dissolution of the drug substance. Disintegrants are vital excipients for tablets. Examples of common and most used disintegrants are L-HPC (Low-Substituted Hydroxypropyl Cellulose), Microcrystalline Cellulose, Starch Pregelatinized Modified etc. Excipients represent the complement of the active principle in any pharmaceutical form. Their function is to provide stability, protection, and to ensure absorption of the drug and acceptability in patients. Cellulose is a conventional excipient in many pharmaceutical solid dosage products. Most of the sources used to extract microcrystalline cellulose come from cotton or wood, which are.

According to many publications, microcrystalline cellulose is an excipient of outstanding merit. It possesses the following desirable properties: It has the highest compressibility potential of all, known direct compression excipients and it can be directly compressed without addition of binder.   Microcrystalline cellulose (MCC) has developed as the most ingenious excipient for pharma industry. B ecause of its characteristics and grades, it . We offer Microcrystalline Cellulose, Magnesium Stearate, Dicalcium Phosphate and Firmapress in our range of excipients.. Microcrystalline Cellulose is a binding agent, which holds the content of the tablet together. Dicalcium Phosphate is a flowing agent and helps move ingredients through the machine before they are compressed. SANCEL ® Microcrystalline cellulose is widely used in pharmaceuticals, primarily as a binder/diluent in oral tablet and capsule formulations where it is used in both wet-granulation and direct-compression processes. SANCEL ® is the preferred excipient for use in tablets, capsules, granules, pellets & spheres, as it enhances the adsorption.